Paraoxonase 1 (PON1) modulates the toxicity of mixed organophosphorus compounds
نویسندگان
چکیده
منابع مشابه
Serum paraoxonase 1 (PON1) measurement: an update
Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in vascular disease, as well as its use as biomarker of diseases involving oxidative stress, inflammation and liver diseases.This review provides an update about the current knowledge in the field of the analytical procedures that are...
متن کاملParaoxonase 1 (PON1), agricultural organophosphate exposure, and Parkinson disease
Background—Human, animal and cell models support a role for pesticides in the etiology of Parkinson disease. Susceptibility to pesticides may be modified by genetic variants of xenobiotic enzymes, such as paraoxonase, that play a role in metabolizing some organophosphates. Methods—We examined associations between Parkinson disease and the organophosphates diazinon, chlorpyrifos, and parathion, ...
متن کاملHomocysteine levels, paraoxonase 1 (PON1) activity, and cardiovascular risk.
lyzed our study population by dividing the births within each gestational age category into smaller and larger birth weights by their z score of birth weight by gestational age. Adjusting for gestational week within each category as well as year of birth, larger infants did have the best survival for any given gestational age. For 22 to 27, 28 to 32, 33 to 36, and 37 to 42 weeks, the relative r...
متن کاملAlzheimer’s Disease and Paraoxonase 1 (PON1) Gene Polymorphisms
BACKGROUND Some studies have indicated that human paraoxonase 1 (PON1) activity shows a polymorphic distribution. The aim of this study was to determine the distribution of PON1 polymorphism in patients with Alzheimer's disease in Gorgan and compare it with a healthy control group. METHOD The study included 100 healthy individuals and 50 patients. Enzyme activity and genetic polymorphism of P...
متن کاملPolymorphisms in the human paraoxonase (PON1) promoter.
Paraoxonase (PON1) is a protein component of high-density lipoprotein (HDL) particles that protects against oxidative damage to both low-density lipoprotein and HDL and detoxifies organophosphorus pesticides and nerve agents. A wide range of expression levels of PON1 among individuals has been observed. We examined the promoter region of PON1 for genetic factors that might affect PON1 activity ...
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ژورنال
عنوان ژورنال: Toxicology and Applied Pharmacology
سال: 2009
ISSN: 0041-008X
DOI: 10.1016/j.taap.2009.02.001